Contextualization Procedure and Modeling of Monocyte Specific TLR Signaling

Contextualization Procedure and Modeling of Monocyte Specific TLR Signaling

Innate immunity is the first line of defense against invasion of pathogens. Toll-like receptor (TLR) signaling is involved in a variety of human diseases extending far beyond immune system-related diseases, affecting a number of different tissues and cell-types. Computational models often do not account for cell-type specific differences in signaling networks. Investigation of these differences...

Improvement of database administration by procedure contextualization

Database Administrators (DBAs) relieve on a large set of procedures for incident solving in database. However, in the one hand, they have to work under temporal and financial pressures, and, in the other hand, DBAs are continually readjusting these procedures to manage a multitude of specific situations that differ from the generic situation by some few contextual elements. The exceptions are r...

TLR Signaling Paralyzes Monocyte Chemotaxis through Synergized Effects of p38 MAPK and Global Rap-1 Activation

Toll-like receptors (TLRs) that recognize pathogen associated molecular patterns and chemoattractant receptors (CKRs) that orchestrate leukocyte migration to infected tissue are two arms of host innate immunity. Although TLR signaling induces synthesis and secretion of proinflammatory cytokines and chemokines, which recruit leukocytes, many studies have reported the paradoxical observation that...

TLR signaling pathways.

Toll-like receptors (TLRs) have been established to play an essential role in the activation of innate immunity by recognizing specific patterns of microbial components. TLR signaling pathways arise from intracytoplasmic TIR domains, which are conserved among all TLRs. Recent accumulating evidence has demonstrated that TIR domain-containing adaptors, such as MyD88, TIRAP, and TRIF, modulate TLR...

Roles in TLR Signaling Pathway